Abstract

The analysis of Bio-sensors are to gain an understanding of Integrated optical structure to convert biological sample response into an measurable electrical signal. The present technology developed in Integrated optical structure based Surface Plasmon Resonance (SPR) sensors. SPR sensors are very small size, low cost and ruggedness. It can improved by designing and analysis for optical structure platform. In this review Optical Integrated Structure waveguide as a dielectric material with high Refractive Index enclosed on all sides and metal bounded on all sides by materials with lower Refractive Index, i.e. base material substrate and the medium to be sense. Optical bio-sensors are prone to noise which arise due to mechanical vibrations, spatial intensity fluctuations of the light source, thermal drift and change in refractive index of the bulk analyte solution. The main applications are detection of bio samples such as a analyte. The analysis of optical sensor growth in the field of SPR sensor, Lab On Chip design and new materials to afford the benefits. In this paper review basic fundamentals of SPR principle technology and sensing analysis briefly discussed and also leading to the integration of sensitive SPR to Lab-On- Chip designs.